Antibiotic treatment of appendicitis

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Antibiotic Therapy as Single Treatment of Acute Appendicitis

BACKGROUND Appendectomy has been the established treatment of acute appendicitis during the last century, regarded as a simple and safe procedure, although hampered with postoperative complications and increased standard mortality. Modern research has indicated that selected patients with acute appendicitis can be treated by antibiotic therapy alone. The aim of this thesis was therefore to expl...

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Meta-analysis of the therapeutic effects of antibiotic versus appendicectomy for the treatment of acute appendicitis

Appendicectomy has been the gold standard treatment of acute appendicitis for more than a century, while nonoperative therapies, including antibiotics, have acquired increased interest in recent years. The present meta-analysis aimed to compare the therapeutic effects of antibiotics versus appendicectomy for the treatment of acute appendicitis. Medline, Embase and The Cochrane Library databases...

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Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial.

IMPORTANCE An increasing amount of evidence supports the use of antibiotics instead of surgery for treating patients with uncomplicated acute appendicitis. OBJECTIVE To compare antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis confirmed by computed tomography (CT). DESIGN, SETTING, AND PARTICIPANTS The Appendicitis Acuta (APPAC) multicenter, open-labe...

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Oral metronidazole as antibiotic prophylaxis for patients with nonperforated appendicitis

BACKGROUND The rate of wound infection after appendectomy without antibiotic prophylaxis is 10%-30%. The role of prophylactic antibiotic therapy in nonperforated appendicitis is still controversial. Metronidazole is against anaerobic organisms and its bioavailability after oral and parenteral administration has been shown to be similar. The objective of the present study is to compare the infec...

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ژورنال

عنوان ژورنال: The Journal of Pediatrics

سال: 2016

ISSN: 0022-3476

DOI: 10.1016/j.jpeds.2016.06.074